PYREXIA OF UNKNOWN ORIGIN- CAUSES
Definition:
Criteria for definition of PUO
1.illness of more than 3wks duration
Temp>38.3ºC on several occasions
Remaining
undiagnosed after 1weekof intensive study in hospital.
Most causes of PUO are
unusual
presentation of common diseases or
one of the group of the diseases which are difficult
to diagnose
.Infections,malignancies and collagen vascular
diseases are common causes.
Causes
of PUO:
1.Infections:
Especially TB,infective
endocarditis,Brucellosis,localized abscesss,HIV,
Relapsing
fever,EBV,CMV,cholangitris,enteric fever
2.Malignancy
Hodgkins disease
Lymphoma,leukemia renal
carcinoma,hepatoma
3.collagen
vascular diseases
Especially Stills diseas,SLE,rheumatoid
arthritis,temporal arteritis
4.
Drugs-virtually any drug
5.
Factititious fever
6
.Sarcoidosis
7.
Endocrine disease- pheochromocytoma,thyrotoxicosis
7.Rarely:
a) familial
Mediterranean fever
b). whipples disease
c) Weber –Christian disease
Munchausens syndrome
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